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Autism Under the GnuPharma Model

Autism is a medical condition which is extremely complicated and complex, or is it?  It is almost undoubtedly caused by oxidative stress which impacts metabolism.  

 We readily understand that if we do not put oil in our cars that we will have issues.  Our cars will not run as intended.  Oil is integral to the function of the engine and without it the engine will break down. If we look at the “most important” function our bodies perform, that function might be something called delta 6 desaturase.  Certainly “breathing” is critical, but so is the enzyme that we use to cleave the only 2 fatty acids our bodies cannot make.  Omega 3 and omega 6 fatty acids are called essential fatty acids due to the fact that we have to have them and that our bodies cannot make them.  In order to “deal” with them, we have to have an enzyme called delta 6 desaturase.  This enzyme is expressed by the FADS2 gene which is impacted in severe autism (1).  A delta 6 desaturase deficiency is directly tied to autism (2).  So what happens if the delta 6 desaturase enzyme is inefficient or is not expressed at all? If your body cannot deal with omega 3 fatty acids, that means you will not be able to build ANY of your first line ANTI-inflammatory mediators.  Your ability to deal with trauma, infections, parasites, and viruses will be impacted.  About 80% of us will currently die of some inflammatory disease, so omega 3’s are super important to our function given today’s diet.  If your body cannot deal with omega 6 fatty acids, that means you cannot build any inflammatory mediators.  Further, your two main endocannabinoids, called anandamide and 2-ag, are built from omega 6 fatty acids. So severely autistic folks cannot “inflame” or “deflame”, which means they cannot run a basic immune system.  They have deficiencies in their endocannabinoid system with the two main molecules needed to run the endocannabinoid system.  These deficiencies cause a “lack of control” in the master regulatory system.   What happens is, because of these very severe deficiencies, autistic folks EVOLVE.  They build an “alternative ” immune system.  The primary anti-inflammatory is something we all make, but they will make in abundance, called propionic acid.  Propionic acid, because it is so highly anti-inflammatory, probably saves their lives.  However, propionic acid is what is used to CAUSE autism in the rat model of autism (3).  This is the very reason that some “microbiome” strategies for autism will show some progress and then rebound. When we consider autism under the GnuPharma model, we want to get it at its “source” which is the metabolic issue of delta 6 desaturase.  Re-righting this imbalance will cause functions to come into balance and the “need” to over produce propionic acid will abate. Our strategy is an intervention, management, then maintenance model.  Every autistic situation is different.  This requires some discussion (and ideally testing) on the front end.  An intervention plan, usually with a natural product, a management plan, and then maintenance.  Management and maintenance could be as simple as diet changes or as complex as mold testing and other environmental considerations.  Diet and environment is how we are both affected and influenced. If you are a family impacted by autism, please consider signing up for our program.  It starts with a consultation and we will work with you until we find the products which will cause the most progress quickest.

Supporting Data:


Focus For Autism, But I’m Not Autistic?

Truemedx Line Of Focus Products

      Truemedx has formulated some seriously powerful natural medicine. The Focus line of products are formulated to target the severly disregulated Endocannabinoid System of Autistic people. The formulators at Truemedx have discovered an ancient disregulation in people with Autism that needs to be addressed using much more basic resources like Fats! 

Truemedx Focus Tablets

      Even though I consume my fair share of cannabinoids throughout the day, I was still feeling anxious and depressed.  When Truemedx first came out with their line of Focus products I was immediately hooked on the Focus Tincture. I saw the benefits of taking a high CBG & CBD tincture that was formulated in Hemp Oil. I have always struggled with anxiety and depression. Therefor I am always eager to get my hands on quality natural medicine. To me, the focus products were just that, very high quality natural medicine. I was drawn to the research and how Truemedx goes about creating their products. I could see, and feel from the products, Truemedx is on to something.

      As the research progressed it became very clear that the answer wasn’t more cannabinoids. It was actually more healthy fats! What we discovered is when humans are denied these fats they begin to break down. Humans will start breaking down in their gut and in their cognitive abilities. We need to be eating a balanced 1:1 diet of Omega 3 & 6 Fatty Acids. Currently we are at about 1:20. For every 1 Omega 3 we eat, we eat about 20 Omega 6’s. There are other Fatty Acids we need such as polyunsaturated fats and monounsaturated fats.

Healthy Fats

      The Focus tablets contain no cannabinoids, only fats we need to function properly. Ideally I would be getting these from the food I eat but my diet isnt all that great. The focus tablets provide the resources I need that I cant get from cannabis and have a really hard time getting in the common western diet. Since I started using the focus tablets I have seen a dramatic increase in energy, over-all mood has greatly improved, and I can focus better for longer. I dont notice the increase in Focus unless I am reading, working on the computer or studying. Surprise! You actually have to try and focus to notice the increase in focus! 

Focus For You

      Truemedx Focus Products work without any cannabinoids because resources are provided at a very high level. These specific resources support the function of our Endocannabinoid System so we can break down and use cannabinoids more efficiently. If you are finding that your current CBD or natural product regimen isn’t working please contact us. We will consult with you to help discover what products will work the best for you. Often we find that it is the additional herbs and fruit oils that give us the natural benefits over other products. 

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Metabolism & Autism

Because autism is a very complex disease, it requires the autistic individual to “evolve” in order to survive.  Without the capacity to build anti-inflammatories from fatty acids, the autistic individual is forced to adapt through changes in the production of short chain fatty acids in the gut which help with inflammation.  While this change saves their lives, it also contributes to the symptoms of autism.

Autism is a very complicated and complex set of disorders that stem from needed genetic expressions being turned off, needed genetic expressions being improperly encoded, or unneeded genetic expressions improperly turned on.  By virtue of these improper genetic expressions, the autistic individual’s body, from metabolism to the highest functions, has to adapt to survive.

The human body is a very delicate thing, but also a very resilient thing.  Every time you eat, you change your genetic expression.  If you walk over a lead mine, your genetic expression will change and adapt.  If you are a cigarette smoker, your genetic expressions will change.  If you have allergies, your genetic expression will change.  

How we “metabolize” what we eat is also a very big part of this picture and is determined by diet and by environment.  For instance, athletes will crave sugars and carbohydrates as those provide “quick energy” for athletic endeavors.  Someone who lives in a cold climate will crave fatty foods.  We pay very little attention to this now, but we really should start paying more attention.  Consider this…

A group of humans lives in a jungle abundant with fruits but has very little proteins or sources of fats.  If all those humans ate were fruits, they would be well satisfied.  However, every time they ate fatty acids, their bodies would want to store that precious commodity for future use.  There would be very little need to use a stored fatty acid and most of the bodily processes are running on the fruits=sugars as fuels.  So the body stores the fatty acids and these human would get obese in abundance.

Well, guess what?  Check out the food labels of the things you eat.  Sugar, carbo’s, high fructose corn syrup, sugar, sugar, sugar, sugar.  We are getting fat in abundance and it is killing us.  Further, what ails most of us due to the above is exactly what ails someone affiliated with autism.  In fact, autistic people have alot of trouble just processing fatty acids.  There are several reasons for this and all are addressed by the Focus Metabolic Powder.

In a way, autism is an evolution.  It is a chain reaction of circumstances that happen within the body in order to save that person’s life.  Interestingly, many other “genetic” and neurodegenerative diseases may be linked back to diet, environment, and the resulting genetics changes.A

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